The Synergistic Impact of Late Life Vision Impairment and Genetic Risk on Cognitive Decline and Dementia
Joshua Ehrlich
Assistant Professor, Department of Ophthalmology & Visual Sciences, Medical School
Research Assistant Professor, Survey Research Center, Institute for Social Research
Research Assistant Professor, Survey Research Center, Institute for Social Research
Abstract
This pilot study will test the central hypothesis that vision impairments is a “second hit” that potentiates the risk of cognitive decline and dementia among those that carry the APOE ε4 allele. This hypothesis will be tested using data from the nationally-representative Health and Retirement Study and its sub-study, the Aging, Demographics and Memory Study.
Outcomes
- Ehrlich JR, Kolli A, Zhou Y, Chung G, Ware E. The Joint Effects of Vision Impairment and Apolipoprotein E on the Hazard of Incident Cognitive Impairment. Scientific Poster. Association for Research in Vision and Ophthalmology Annual Meeting. Denver, CO, May 1-4, 2022.
- Ehrlich JR, Swenor BK, Zhou Y, Langa KM. The Longitudinal Association of Vision Impairment With Transitions to Cognitive Impairment and Dementia: Findings From the Aging, Demographics and Memory Study. The journals of gerontology. Series A, Biological sciences and medical sciences. 2021 November 15;76(12):2187-2193. PubMed PMID: 34061956; PubMed Central PMCID: PMC8599065; DOI: 10.1093/gerona/glab157.